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Schematic describing a model by which spermidine regulates mitochondrial ROS production and GA biosynthesis by hypusinating eIF5A in Ganoderma lucidum. Spermidine maintains mitochondrial ROS homeostasis through the regulation of translation and subsequent activity of complexes I and II by hypusinating eIF5A and regulates GA biosynthesis by mitochondrial ROS signaling. OXPHOS, oxidative phosphorylation; eIF5AD, deoxyhypusinated eIF5A; eIF5AH, hypusinated eIF5A.
