Table 1 |.
−log10(P) association statistics for the top Tractor SNP at known risk loci
| trait | Locus | ATT | SNP1 | Tractor |
|---|---|---|---|---|
|
| ||||
| Total cholesterol | APOE | 30.6 | 30.3 (−1.0%) | 28.9 (−5.6%) |
| LDL | APOE | 50 | 49.8 (−0.5%) | 47.5 (−5.1%) |
| Total cholesterol | LDLR | 8.3 | 8.2 (−0.9%) | 7.6 (−8.4%) |
| LDL | LDLR | 9.6 | 9.6 (−0.8%) | 8.8 (−8.9%) |
| Total cholesterol | PCSK9 | 9.4 | 8.5 (−9.9%) | 7.7 (−18.3%) |
| LDL | PCSK9 | 9.6 | 9.4 (−1.3%) | 8.5 (−10.9%) |
| Total cholesterol | SORT1 | 5.1 | 5.0 (−0.9%) | 4.3 (−15.7%) |
| LDL | SORT1 | 7.1 | 7.1 (−0.5%) | 6.3 (−11.7%) |
| Average relative difference | −2.0% | −10.6% | ||
We considered three GWAS tests with correction for global ancestry (ATT), global and local ancestry (SNP1) and global and local ancestry while allowing for heterogeneous effects (Tractor). The index SNP was selected based on the strongest Tractor association P value. Relative differences to the ATT score are shown in parentheses and in the last row.