TABLE 7.
Nature and incidence of treatment-related laboratory abnormalities in children treated with fluconazole
| Parameter | No. of patients tested | No. (%) of patients with abnormalitiesa |
|---|---|---|
| Hematology | ||
| Hemoglobin concn | 547 | 4 (0.7) |
| Leukocyte count | 542 | 0 |
| Neutrophil count | 473 | 0 |
| Eosinophil count | 470 | 6 (1.3) |
| Platelet count | 539 | 5 (0.9) |
| Hepatic function | ||
| AST (SGOTb) level | 490 | 13 (2.7) |
| ALT (SGPTc) level | 472 | 23 (4.9) |
| Alkaline phosphatase level | 428 | 10 (2.3) |
| Total bilirubin concn | 405 | 5 (1.2) |
| Renal function | ||
| Blood urea nitrogen concn | 193 | 1 (0.5) |
| Urea concn | 13 | 0 |
| Creatinine concn | 525 | 0 |
a
Laboratory abnormalities were not necessarily reported as side effects.
b
SGOT, serum glutamic oxalacetic transaminase.
c
SGPT, serum glutamic pyruvic transaminase.