TABLE 8.
Nature and incidence of treatment-related side effects in comparative studies
| Group or parameter | No. (%) of patients
|
|
|---|---|---|
| Fluconazoletreated group | Comparison group | |
| All patients assessed | 382 | 381 |
| Patients with side effects | 45 (11.8)a | 25 (6.6)a |
| Patients withdrawn because of side effects | 15 (3.9) | 5 (1.3) |
| Total side effects | 57 | 33 |
| Gastrointestinal system | ||
| Vomiting | 16 (4.2) | 12 (3.1) |
| Diarrhea | 11 (2.9) | 7 (1.8) |
| Abdominal pain | 9 (2.4) | 4 (1.0) |
| Other gastrointestinal | 10 | 5 |
| Skin | 5 | 0 |
| Liver and biliary | 3 | 0 |
| Respiratory | 2 | 2 |
| Central and peripheral nervous | 1 | 1 |
| Musculoskeletal | 0 | 2 |
a
Chi-square test value = 6.234 (P value < 0.02).