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. 2021 Dec 2;42(4):484–501. doi: 10.1161/ATVBAHA.121.317007

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© 2021 The Authors.

Arteriosclerosis, Thrombosis, and Vascular Biology is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Overview of independent loci identified for carotid intima-media thickness (cIMT). A, Overlaps of independent loci identified between genome-wide association study (GWAS) for three cIMT phenotypes. Each locus is marked with the nearest protein-coding gene to the lead variant. Genes marked in bold red font were the closest genes from the respective lead variants of novel loci. B, Candidate genes from main GWAS, meta-analyses, and sex interaction analysis were manually grouped into functional categories relevant to atherosclerosis. Genes marked in bold red font were from novel loci; *genes discovered in the meta-analysis of UKB (UK Biobank) and CHARGE (Cohorts for Heart and Aging Research in Genomic Epidemiology)/UCLEB (UCL-LSHTM-Edinburgh-Bristol) consortia; †discovered in meta-analysis of three cIMT measurements; ‡sex-specific locus; §genes discovered in transcriptome-wide association study (TWAS) not belonging to any GWAS loci. Parts of the figure were modified from materials provided by Servier Medical art, licensed under a Creative Common Attribution 3.0 Generic License (http://servier.com/Powerpoint-image-bank). max indicates average of maximum cIMT; mean, average of mean cIMT; and min, average of minimum cIMT.