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Mechanistic location of therapeutic targets for PrP prion diseases. Therapeutic targets: ❶ PrPC post-translational processing, metabolism, cellular trafficking, or localization; ❷ PrPC by binding or inducing conformational change that prevents PrPC interaction; ❸ PrPSc by stabilization, redistribution; ❹ conversion process by blocking binding site on PrPC, capping growth, inhibition of cofactor interactions, or ❺ promoting fragmentation or ❻ clearance from the host.
