Table 2.
Associations Between Biomarkers and Ischemic Stroke Using Conditional Logistic Regression With the Imputed Data Set and All Participants Included (n=125)
| Biomarker | OR (95% CI) | P Value | Model 1: Adjusted for Age and Sex AOR (95% CI) | P Value | Model 2: Adjusted for ASCVD Score AOR (95% CI) | P Value | Model 3: Adjusted for VACS Score AOR (95% CI) | P Value |
|---|---|---|---|---|---|---|---|---|
| Log10 viral load | 1.84 (1.13–3.01) | .01 | 2.15 (1.18–3.92) | .01 | 2.11 (1.16–3.84) | .01 | 1.29 (0.73–2.27) | .38 |
| Log10 peak viral load | 1.33 (0.90–1.97) | .16 | 1.45 (0.94–2.24) | .09 | 1.33 (0.86–2.07) | .20 | 1.25 (0.78–2.00) | .35 |
| CD4 count, per 100 cells | 0.90 (0.79–1.03) | .12 | 0.87 (0.75–1.01) | .06 | 0.87 (0.74–1.02) | .09 | 1.06 (0.91–1.24) | .43 |
| Nadir CD4 count, per 100 cells | 0.67 (0.49–0.94) | .02 | 0.69 (0.49–0.98) | .04 | 0.65 (0.45–0.95) | .03 | 0.84 (0.57–1.24) | .37 |
| Log2 angiopoietin-1 | 0.91 (0.68–1.24) | .57 | 0.92 (0.67–1.28) | .64 | 0.90 (0.63–1.29) | .57 | 1.05 (0.74–1.48) | .79 |
| Log2 angiopoietin-2 | 1.63 (1.05–2.52) | .03 | 1.73 (1.05–2.86) | .03 | 2.07 (1.16–3.68) | .01 | 0.97 (0.57–1.67) | .92 |
| Log2 C-reactive protein | 1.11 (0.95–1.30) | .20 | 1.12 (0.93–1.36) | .23 | 1.14 (0.95–1.37) | .15 | 1.02 (0.84–1.24) | .85 |
| Log2 interleukin-6 | 1.42 (1.02–1.96) | .04 | 1.36 (0.95–1.94) | .10 | 1.77 (1.15–2.73) | .01 | 1.06 (0.71–1.57) | .79 |
| Log2 plasma activation inhibitor-1 | 0.79 (0.54–1.13) | .20 | 0.86 (0.57–1.31) | .49 | 0.81 (0.51–1.29) | .37 | 0.93 (0.58–1.51) | .78 |
| Log2 P-selectin | 1.30 (0.69–2.46) | .42 | 1.16 (0.57–2.35) | .68 | 0.97 (0.47–2.01) | .94 | 1.18 (0.55–2.53) | .67 |
| Log2 soluble ICAM-1 | 1.49 (0.81–2.75) | .20 | 1.42 (0.74–2.71) | .29 | 1.94 (0.91–4.10) | .08 | 0.94 (0.43–2.05) | .87 |
| Log2 soluble VCAM-1 | 1.10 (0.65–1.86) | .73 | 1.16 (0.67–2.02 | .60 | 1.51 (0.75–3.03) | .24 | 0.54 (0.26–1.14) | .11 |
| Log2 serum amyloid A | 1.17 (0.97–1.41) | .10 | 1.20 (0.96–1.48) | .10 | 1.26 (1.01–1.57) | .04 | 1.07 (0.86–1.34) | .53 |
| Log2 soluble CD14 | 1.91 (0.84–4.35) | .13 | 2.57 (1.01–6.49) | .05 | 2.69 (0.92–7.85) | .07 | 0.86 (0.32–2.33) | .77 |
| Log2 apolipoprotein A1 | 0.75 (0.33–1.71) | .50 | 0.78 (0.31–1.93) | .59 | 0.77 (0.29–2.04) | .60 | 0.62 (0.22–1.77) | .37 |
| Log2 ADAMTS-13 | 1.37 (0.66–2.84) | .39 | 1.59 (0.72–3.52) | .26 | 2.25 (0.86–5.86) | .10 | 1.48 (0.60–3.64) | .40 |
| Log2 von Willebrand factor | 1.75 (1.09–2.79) | .02 | 1.75 (1.03–2.97) | .04 | 1.74 (1.01–2.98) | .05 | 1.80 (1.04–3.12) | .04 |
Abbreviations: AOR, adjusted odds ratio; ASCVD, Atherosclerotic Cardiovascular Disease score; CD4, cluster of differentiation 4; OR, odds ratio; VACS, Veterans Aging Cohort Study.