. 2021 Oct 21;8(11):ofab521. doi: 10.1093/ofid/ofab521

Table 3.

Associations Between Biomarkers and Ischemic Stroke Using Conditional Logistic Regression With the Imputed Data Set, Restricted to Matched Cases and Controls Whose Viral Load Was <400 Copies/mL (n=89)

Biomarker	OR (95% CI)	P Value	Model 1: Adjusted for Age and Sex, AOR (95% CI)	P Value	Model 2: Adjusted for ASCVD Score, AOR (95% CI)	P Value	Model 3: Adjusted for VACS Score, AOR (95% CI)	P Value
Log₁₀ viral load	2.79 (0.65–11.9)	.17	3.56 (0.62–20.4)	.16	2.74 (0.36–21.2)	.33	1.34 (0.24–7.38)	.74
Log₁₀ peak viral load	1.10 (0.72–1.68)	.66	1.18 (0.75–1.86)	.48	0.90 (0.51–1.61)	.73	1.15 (0.71–1.86)	.56
CD4 count, per 100 cells	0.98 (0.85–1.14)	.83	0.97 (0.82–1.13)	.66	0.98 (0.81–1.18)	.83	1.12 (0.93–1.33)	.23
Nadir CD4 count, per 100 cells	0.74 (0.50–1.10)	.14	0.77 (0.51–1.15)	.21	0.78 (0.49–1.25)	.30	0.83 (0.54–1.29)	.41
Log₂ angiopoietin-1	0.90 (0.64–1.27)	.55	0.93 (0.64–1.36)	.72	0.87 (0.56 –1.36)	.54	1.05 (0.72–1.54)	.80
Log₂ angiopoietin-2	1.33 (0.85–2.06)	.21	1.46 (0.87–2.46)	.15	1.72 (0.96–3.10)	.07	0.95 (0.57–1.60)	.86
Log₂ C-reactive protein	1.13 (0.92–1.39)	.25	1.18 (0.92–1.52)	.20	1.15 (0.89–1.48)	.28	1.08 (0.85–1.38)	.51
Log₂ interleukin-6	1.16 (0.81–1.67)	.41	1.15 (0.77–1.72)	.49	1.31 (0.79–2.18)	.30	0.96 (0.63–1.48)	.86
Log₂ plasma activation inhibitor–1	0.73 (0.46–1.15)	.17	0.81 (0.48–1.37)	.44	0.70 (0.37–1.34)	.29	0.92 (0.52–1.63)	.79
Log₂ P-selectin	1.19 (0.58–2.46)	.64	0.97 (0.43–2.19)	.94	0.72 (0.28–1.88)	.50	1.06 (0.48–2.34)	.89
Log₂ soluble ICAM-1	1.30 (0.58–2.90)	.52	1.19 (0.50–2.88)	.69	1.48 (0.53–4.15)	.46	0.98 (0.36–2.64)	.97
Log₂ soluble VCAM-1	0.98 (0.51–1.91)	.96	1.00 (0.49–2.07)	.99	1.24 (0.54–2.84)	.61	0.41 (0.15–1.11)	.08
Log₂ serum amyloid A	1.09 (0.86–1.40)	.47	1.15 (0.86–1.54)	.36	1.15 (0.86–1.55)	.34	1.05 (0.80–1.38)	.71
Log₂ soluble CD14	1.35 (0.52–3.49)	.54	1.89 (0.61–5.88)	.27	1.84 (0.51–6.65)	.35	0.60 (0.18–2.00)	.40
Log₂ apolipoprotein 1	0.77 (0.27–2.17)	.62	0.73 (0.23–2.35)	.60	0.93 (0.24–3.57)	.92	0.58 (0.16–2.02)	.39
Log₂ ADAMTS-13	1.29 (0.55–3.02)	.56	1.41 (0.55–3.62)	.47	2.16 (0.63–7.36)	.22	1.62 (0.60–4.38)	.35
Log₂ von Willebrand factor	1.61 (0.99–2.62)	.06	1.60 (0.90–2.82)	.11	1.64 (0.88–3.05)	.12	1.59 (0.93–2.74)	.09

Abbreviations: AOR, adjusted odds ratio; ASCVD, Atherosclerotic Cardiovascular Disease score; CD4, cluster of differentiation 4; OR, odds ratio; VACS, Veterans Aging Cohort Study.