Table 2. Immunocompromised patient characteristics with a first diagnosis of a condition for which pneumococcal vaccination is recommended as per STIKO guidelines.
| Cohort A | Cohort B | ||
|---|---|---|---|
| Gender and age group distribution n, (%) | Total number of subjects | 193,521 (100.0%) | 289,279 (100.0%) |
| Male | 86,349 (44.6%) | 132,710 (45.9%) | |
| Female | 107,172 (55.4%) | 156,569 (54.1%) | |
| Age 2–15 | 10,225 (5.3%) | 12,053 (4.2%) | |
| Age 16–59 | 113,955 (58.9%) | 157,980 (54.6%) | |
| Age ≥60 | 69,341 (35.8%) | 119,246 (41.2%) | |
| Conditions (congenital or acquired) resulting in immunodeficiency at index date n, (%) * | Functional or anatomic asplenia sickle cell diseases and other hemoglobinopathies | 1,966 (1.0%) | 2,966 (1.0%) |
| Other immunodeficiency | 105,977 (54.8%) | 148,717 (51.4%) | |
| Malignant neoplasms excluding non-melanoma skin cancer | 39,619 (20.5%) | 60,070 (20.8%) | |
| Stem cell transplantation | 10 (0.0%) | 18 (0.0%) | |
| HIV infection | 832 (0.4%) | 1,040 (0.4%) | |
| Chronic renal failure | 35,644 (18.4%) | 64,701 (22.4%) | |
| Chronic severe liver disease | 7,311 (3.8%) | 10,654 (3.7%) | |
| Immunosuppressant use | 7,498 (3.9%) | 10,831 (3.7%) | |
| Chronic disease conditions n, (%) * | No relevant chronic disease | 91,853 (47.5%) | 129,140 (44.6%) |
| Patient has a relevant chronic disease | 101,668 (52.5%) | 160,139 (55.4%) | |
| Chronic heart disease | 45,450 (23.5%) | 77,135 (26.7%) | |
| Chronic pulmonary disease | 57,545 (29.7%) | 88,131 (30.5%) | |
| Diabetes treated with oral antidiabetics or insulin | 21,017 (10.9%) | 36,527 (12.6%) | |
| Neurological disorders | 24,445 (12.6%) | 43,391 (15.0%) | |
*The same patient may appear in several different subgroups.