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. 2022 Mar 18;15:1935–1941. doi: 10.2147/JIR.S356316

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© 2022 Zhang et al.

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(A) Normal hair follicles. (B) Hair follicles of patients with alopecia areata. Tumour, infection, stress, and other factors interfere with the immune environment. T lymphocytes, natural killer (NK) cells, and CD8⁺ NK group 2, member D (NKG2D)⁺ T lymphocytes congregate around hair follicles to produce interferon gamma (IFN-γ). MHC-I expression is thus upregulated.