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. Author manuscript; available in PMC: 2022 Apr 1.
Published in final edited form as: Trends Biochem Sci. 2022 Feb 19;47(4):314–327. doi: 10.1016/j.tibs.2022.01.002

BOX 1 Figure. Sequence conservation and domain structure of human Mediator kinase module subunits.

BOX 1 Figure.

Regions marked “disordered” are predicted to be intrinsically disordered, and defined domains are individually labeled. Evolutionary conservation was calculated from 150 homologs of at least 35% identity, using ConSurf [120]. Sequence identity between paralogs is noted.