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. 2011 May 11;2011(5):CD008063. doi: 10.1002/14651858.CD008063.pub2

Summary of findings for the main comparison. motivational interviewing compared to no treatment control group for substance abuse.

motivational interviewing compared to no treatment control group for substance abuse
Patient or population: patients with substance abuse 
 Settings:Intervention: motivational interviewing 
 Comparison: no treatment control group
Outcomes Illustrative comparative risks* (95% CI) Relative effect 
 (95% CI) No of Participants 
 (studies) Quality of the evidence 
 (GRADE) Comments
Assumed risk Corresponding risk
no treatment control group motivational interviewing
amount of substance abuse post intervention   The mean amount of substance abuse post intervention in the intervention groups was 
 0.79 standard deviations lower 
 (0.48 to 1.09 higher)   202 
 (4 studies) ⊕⊕⊝⊝ 
 low1,2  
amount of substance abuse short follow‐up 
 Follow‐up: 1‐6 months   The mean amount of substance abuse short follow‐up in the intervention groups was 
 0.17 standard deviations lower 
 (0.09 to 0.26 higher)   2327 
 (15 studies) ⊕⊕⊕⊝ 
 moderate1  
amount of substance abuse medium follow‐up 
 Follow‐up: 7‐12 months   The mean amount of substance abuse medium follow‐up in the intervention groups was 
 0.15 standard deviations higher 
 (0.04 to 0.25 higher)   2326 
 (12 studies) ⊕⊕⊝⊝ 
 low1  
amount of substance abuse long follow‐up 
 Follow‐up: mean 12 months   The mean amount of substance abuse long follow‐up in the intervention groups was 
 0.06 standard deviations lower 
 (0.16 lower to 0.28 higher)   363 
 (1 study) ⊕⊕⊝⊝ 
 low1,3  
Readiness for change   The mean Readiness for change in the intervention groups was 
 0.05 standard deviations higher 
 (0.11 lower to 0.22 higher)   1495 
 (5 studies) ⊕⊕⊝⊝ 
 low4,5  
Retention 
 Follow‐up: 0‐3 months   The mean Retention in the intervention groups was 
 0.26 standard deviations higher 
 (0 to 0.52 higher)   427 
 (2 studies) ⊕⊝⊝⊝ 
 very low4,6,7  
*The basis for the assumed risk (e.g. the median control group risk across studies) is provided in footnotes. The corresponding risk (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). 
 CI: Confidence interval;
GRADE Working Group grades of evidence 
 High quality: Further research is very unlikely to change our confidence in the estimate of effect. 
 Moderate quality: Further research is likely to have an important impact on our confidence in the estimate of effect and may change the estimate. 
 Low quality: Further research is very likely to have an important impact on our confidence in the estimate of effect and is likely to change the estimate. 
 Very low quality: We are very uncertain about the estimate.

1 Unclear randomisation and blinding of assessor. 
 2 Confidence interval from 0.48 to 1.09 
 3 Confidence interval includes both negative and positive values. 
 4 Incomplete outcome data addressed. Unclear allocation concealment and blinding. 
 5 I‐squared = 48%. 
 6 I‐squared = 36%. 
 7 Confidence interval from ‐0.00 to 0.50.