Anton 2005.

Methods	RCT.
Participants	160 outpatient alcoholics from the USA.
Interventions	1. naltrexone + MET (n= 41) 2. placebo + MET (n= 39) 3. naltrexone + CBT (n= 39) 4. placebo + CBT (n= 41)
Outcomes	Physiological primary: Blood GGT, CDT, urine drug screen. Non‐physiological primary: Number relapsed, drinks per drinking day, percent abstinent. Secondary: None.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"Subjects were randomly assigned to 1 of 4 treatment conditions".
Allocation concealment (selection bias)	Unclear risk	Insufficient information to permit judgment.
Blinding (performance bias and detection bias) Patients and providers	Low risk	No blinding, but most outcomes were physiological and also used to validate self‐reports, and not likely to be influenced by lack of blinding.
Blinding (performance bias and detection bias) Assessors	Low risk	Insufficient information to know whether assessors were blinded. But most outcomes were physiological and also used to validate self‐reports, and not likely to be influenced by lack of blinding.
Incomplete outcome data (attrition bias) All outcomes	Low risk	15% attrition at 12 weeks post‐treatment. Balanced across conditions. Reasons addressed. ITT performed. "All outcome analyses were conducted under an intent‐to‐treat analysis plan on all subjects who had at least 1 postrandomization outcome measurement."
Selective reporting (reporting bias)	Unclear risk	The published report included all expected outcomes based on the stated hypotheses.
Other bias	Low risk	Used collateral and biological measurement to corroborate self‐reports of substance use. There were no differences between groups at baseline. No additional sources of bias appear to be present.