Kahler 2004.
Methods | RCT. | |
Participants | 48 US patients undergoing inpatient detoxification for alcohol dependence. | |
Interventions | MET for 12‐step involvement (n= 24) vs brief advice to attend AA (n= 24). | |
Outcomes |
Physiological primary: None. Non‐physiological primary: Percent of days abstinent, drinks per drinking day. Secondary: AA/NA attendance and involvement. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "Eight cohorts of 6 participants were run to obtain the desired sample with treatment conditions for each cohort determined randomly." |
Allocation concealment (selection bias) | Unclear risk | Insufficient information to permit judgment. |
Blinding (performance bias and detection bias) Patients and providers | High risk | No blinding. |
Blinding (performance bias and detection bias) Assessors | Low risk | "RAs (research assistants) were blind to treatment assignment of individuals and cohorts." |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 48 were randomised. Attrition was 4%, 4%, 6%, 6%, 12%, and 12% at 1,2,3,4,5, and 6 months follow‐up, respectively. No reasons for insufficient data reported. No ITT performed. |
Selective reporting (reporting bias) | Low risk | The published report included all expected outcomes based on the study hypotheses. |
Other bias | Unclear risk | Collateral reports were used. However, because the two treatments were of different length, it is not possible to determine whether treatment intensity rather than treatment content caused the observed effects. There were no differences between groups at baseline. |