McCambridge 2008.
Methods | RCT. | |
Participants | 326 young cannabis users aged 16‐19 years not seeking help from eleven London Further Education colleges. UK. | |
Interventions | Single session intervention of MI (n= 164) vs drug information and advice giving (n= 162). | |
Outcomes |
Physiological primary: None (but bogus pipeline). Non‐physiological primary: 30‐day frequency of cannabis use (joints past week), 30‐day alcohol consumption (units of alcohol past week + AUDIT score). Secondary: None. Follow‐ups were at 3 and 6 months. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | "Computerised individual randomisation was undertaken by the local clinical trials unit." |
Allocation concealment (selection bias) | Low risk | "Decisions were communicated on an individual basis via telephone or e‐mail to researchers after recruitment and baseline data collection to preserve allocation concealment." |
Blinding (performance bias and detection bias) Patients and providers | Unclear risk | No blinding but bogus pipeline. |
Blinding (performance bias and detection bias) Assessors | Low risk | "Study participants self‐completed questionnaires which were distributed by a researcher who was blind to study allocation." |
Incomplete outcome data (attrition bias) All outcomes | Low risk | 17% and 19% lost to follow‐up at 3 and 6 months, respectively. Unequal between groups. Reasons for loss‐to‐follow‐up not stated. Intention to treat using last observation carried forward. |
Selective reporting (reporting bias) | Low risk | The published report included all expected outcomes based on the stated hypotheses. |
Other bias | Low risk | A bogus pipeline approach was used in addition to self‐report. There were no differences between groups at baseline. No additional sources of bias appears to be present. |