UKATT 2005.

Methods	Multisite RCT (7 sites).
Participants	742 UK clients with alcohol problems.
Interventions	MET(n= 442) vs social behavior and network therapy (n= 320).
Outcomes	Physiological primary: Gamma‐glutamyl transferase Non‐physiological primary: Days abstinent, number of drinks per drinking day, Leeds Dependence Questionnaire score, alcohol problems score. Secondary: None.
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	"The remote randomisation service at York used a computer "on line" to allocate consenting participants between therapy groups."
Allocation concealment (selection bias)	Unclear risk	"Treatment was concealed until allocation."
Blinding (performance bias and detection bias) Patients and providers	Low risk	No blinding, but most outcomes were physiological and also used to validate self‐reports, and not likely to be influenced by lack of blinding.
Blinding (performance bias and detection bias) Assessors	Low risk	Assessors blinded at 12 months but not at 3 months. But most outcomes were physiological and also used to validate self‐reports, and not likely to be influenced by lack of blinding.
Incomplete outcome data (attrition bias) All outcomes	Low risk	7% attrition at 3 months follow‐up and 17% attrition at 12 months follow‐up. Balanced. Reasons provided. ITT using last observation carried forward performed.
Selective reporting (reporting bias)	Low risk	The published report included all expected outcomes based on the study hypotheses.
Other bias	Low risk	Gamma GT used to check on self‐report. There were no differences between groups at baseline. No additional sources of bias appear to be present.