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(A) Schematic representation of tumor characteristics obtained from CGNPs with perturbed SHH signaling in the presence of absence of increased REST expression. (B) Graphical representation of REST-dependent chromatin remodeling of the Ptch1 gene in WT or RESTTG CGNPs during proliferation and differentiation. (C) Model depicting REST regulation of AKT signaling in SHH-driven MBs.
