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Structures and mechanisms of action of AUs which selectively inhibit the gram-positive pol III. (A) Relevant domains of the AU molecule. (B) Equivalence of the base-pairing domains of the guanine (left) and AU (right) molecules. (C) The AU molecule inhibits its pol III target by sequestering it into an inactive DNA-drug-protein complex. PUR, purine; PYR, pyrimidine. (D) Structures of two relevant AUs, EMAU and TMAU.
