TABLE 3.
In vitro antibacterial activity of N-3-hydroxyalkyl and methoxyalkyl EMAUs
| R group | MIC (μg/ml)a
|
|||||||
|---|---|---|---|---|---|---|---|---|
| B. subtilis BD54 | MSSA (S. aureus IP8) | MRSA6 (S. aureus B42876) | MRSA3 (S. aureus B43243) | E. faecalis ATCC 8043 | VRE | E. faecium ATCC 29212 | E. coli XL1 Blue (Stratagene) | |
| -(CH2)2OH (HE) | 0.7 | 7 | 14 | 14 | 5 | 7 | 7 | >58 |
| -(CH2)2OCH3 (ME) | 0.9 | 15 | 8 | 8 | 6 | 6 | 8 | >61 |
| -(CH2)3OH (HP) | 0.9 | 6 | 8 | 8 | 6 | 6 | 6 | >61 |
| -(CH2)3OCH3 (MP) | 0.5 | 6 | 6 | 6 | 3 | 3 | 6 | >63 |
a
MICs are the medians of three independent experiments performed as described in the Materials and Methods section.