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Kaplan-Meier curves for PFS of afatinib for distinct HER2 ex20ins variants G776delinsVC and A775_G776insYVMA in first-line (A) and second-line setting (B). Kaplan-Meier curves for PFS of pyrotinib vs. afatinib among overall ex20ins patients as first-line (C) and second-line therapy (D).
