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3D-based homology protein models (HER2 wild type marked in yellow, HER2 mutants marked in pink) of HER2 exon 20 Gly776 deletion-insertion variant G776delinsVC with the small molecule TKI afatinib (A), G776delinsVV (B), G776delinsLC (C), compared with the most common 12-bp in-frame insertion A775_G776insYVMA (D).
