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. 2022 Mar 7;13:806737. doi: 10.3389/fphar.2022.806737

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Copyright © 2022 Yang, Xu, Hu, Liu, Hu, Yang, Li, Hao, Zhang, Xu, Ai, Li and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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HER2-targeted TKIs pyrotinib, afatinib, dacomitinib, and poziotinib (A) were performed in cellular kinase inhibition assay to inhibit HER2 wild type (B) and A775_G776insYVMA (C) Ba/F3 cells. IC₅₀ values of above four inhibitors against HER2 wild type and A775_G776insYVMA cells (D).