Figure 6. Within the DNTT locus, many of the significant SNP associations overlapped between N-insertion types when using DNTT gene-level Bonferroni-corrected p-value significance threshold of $1.28\times {10}^{-5}$.

Downward arrows represent promoter/exon starting positions and upward arrows represent promoter/exon ending positions.

Figure 6—figure supplement 1. For these significant DNTT locus SNP associations, the magnitudes of the effects were greater for non-productive TCRs compared to productive TCRs for both V-D-gene junction N-insertion and D-J-gene junction N-insertion.

Figure 6—figure supplement 2. The extent of V-D and D-J N-insertion of productive and non-productive TCRβ chains changes as a function of SNP genotype within the discovery cohort for an intronic DNTT SNP (rs3762093).

The average number of N-insertions was calculated across all TCRβ chains for each subject.

Figure 6—figure supplement 3. An intronic SNP (rs3762093) within the DNTT gene locus is not strongly associated with the number of V-D (A) or D-J (B) N-inserts within productive or non-productive TCRβ chains in the validation cohort.

However, the direction of the effect is the same as the discovery cohort for all N-insertion and productivity types. The average number of N-insertions was calculated across all TCRβ chains for each subject.

Figure 6—figure supplement 4. An intronic SNP (rs3762093) within the DNTT gene locus is significantly associated with the number of V-J N-inserts for productive TCRα chains in the validation cohort.

This SNP is not significantly associated with the number of V-J N-inserts for non-productive TCRα chains in the validation cohort. The average number of N-insertions was calculated across all TCRα chains for each subject.