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. 1999 Aug;43(8):1988–1992. doi: 10.1128/aac.43.8.1988

TABLE 1.

Pharmacokinetic data from assays of plasma and exudate from calves administered enrofloxacin (2.5 mg/kg) and danofloxacin (1.25 mg/kg) by subcutaneous injectiona

Assay Substance Antimicrobial(s) Tmax (h) Cmax (μg/ml) AUCLAST (μg · h/ml) AUMCLAST (μg · h/ml) MRTLAST (h)
HPLC Plasma Enrofloxacin 1.75 ± 1.04 0.242 ± 0.084 1.397 ± 0.245 7.569 ± 2.465 5.522 ± 2.028
Ciprofloxacin 3.25 ± 1.04 0.110 ± 0.029 1.359 ± 0.474 15.338 ± 8.693 10.623 ± 3.575
Danofloxacin 1.25 ± 0.66 0.229 ± 0.050 1.643 ± 0.227 7.685 ± 1.084 4.689 ± 0.433
Enrofloxacin + ciprofloxacin 2.13 ± 1.25 0.338 ± 0.103 2.506 ± 0.427 16.879 ± 6.742 6.753 ± 2.768
Microbiological Plasma Enrofloxacin 2.25 ± 1.17 0.491 ± 0.165 3.116 ± 0.980 14.141 ± 5.983 4.482 ± 0.922
Danofloxacin 1.38 ± 0.52 0.241 ± 0.030 1.383 ± 0.153 4.900 ± 0.551 3.543 ± 0.089
HPLC Exudate Enrofloxacin 2.94 ± 1.86 0.179 ± 0.065 1.478 ± 0.417 13.578 ± 6.925 8.885 ± 2.429
Ciprofloxacin 5.25 ± 1.83 0.104 ± 0.039 1.849 ± 0.927 26.829 ± 17.966 13.744 ± 3.092
Danofloxacin 3.25 ± 2.49 0.192 ± 0.053 2.508 ± 0.658 28.167 ± 12.966 10.720 ± 3.499
Enrofloxacin + ciprofloxacin 3.63 ± 1.51 0.267 ± 0.085 3.330 ± 1.206 43.523 ± 21.744 12.661 ± 2.248
Microbiological Exudate Enrofloxacin (n = 7) 4.00 ± 2.31 0.337 ± 0.087 4.062 ± 1.990 43.146 ± 34.339 9.254 ± 3.546
Danofloxacin 3.668 ± 2.94 0.217 ± 0.039 3.417 ± 0.931 43.414 ± 22.116 11.981 ± 3.408
a

All values are means ± SDs, and the number of samples was 8 unless otherwise indicated. Tmax, time until the maximum concentration was achieved; AUMCLAST, area under the first moment of the concentration-time curve determined to the last measured data point; MRTLAST, mean residence time using data to the last measured concentration.