TABLE 1.
Assay | Substance | Antimicrobial(s) | Tmax (h) | Cmax (μg/ml) | AUCLAST (μg · h/ml) | AUMCLAST (μg · h/ml) | MRTLAST (h) |
---|---|---|---|---|---|---|---|
HPLC | Plasma | Enrofloxacin | 1.75 ± 1.04 | 0.242 ± 0.084 | 1.397 ± 0.245 | 7.569 ± 2.465 | 5.522 ± 2.028 |
Ciprofloxacin | 3.25 ± 1.04 | 0.110 ± 0.029 | 1.359 ± 0.474 | 15.338 ± 8.693 | 10.623 ± 3.575 | ||
Danofloxacin | 1.25 ± 0.66 | 0.229 ± 0.050 | 1.643 ± 0.227 | 7.685 ± 1.084 | 4.689 ± 0.433 | ||
Enrofloxacin + ciprofloxacin | 2.13 ± 1.25 | 0.338 ± 0.103 | 2.506 ± 0.427 | 16.879 ± 6.742 | 6.753 ± 2.768 | ||
Microbiological | Plasma | Enrofloxacin | 2.25 ± 1.17 | 0.491 ± 0.165 | 3.116 ± 0.980 | 14.141 ± 5.983 | 4.482 ± 0.922 |
Danofloxacin | 1.38 ± 0.52 | 0.241 ± 0.030 | 1.383 ± 0.153 | 4.900 ± 0.551 | 3.543 ± 0.089 | ||
HPLC | Exudate | Enrofloxacin | 2.94 ± 1.86 | 0.179 ± 0.065 | 1.478 ± 0.417 | 13.578 ± 6.925 | 8.885 ± 2.429 |
Ciprofloxacin | 5.25 ± 1.83 | 0.104 ± 0.039 | 1.849 ± 0.927 | 26.829 ± 17.966 | 13.744 ± 3.092 | ||
Danofloxacin | 3.25 ± 2.49 | 0.192 ± 0.053 | 2.508 ± 0.658 | 28.167 ± 12.966 | 10.720 ± 3.499 | ||
Enrofloxacin + ciprofloxacin | 3.63 ± 1.51 | 0.267 ± 0.085 | 3.330 ± 1.206 | 43.523 ± 21.744 | 12.661 ± 2.248 | ||
Microbiological | Exudate | Enrofloxacin (n = 7) | 4.00 ± 2.31 | 0.337 ± 0.087 | 4.062 ± 1.990 | 43.146 ± 34.339 | 9.254 ± 3.546 |
Danofloxacin | 3.668 ± 2.94 | 0.217 ± 0.039 | 3.417 ± 0.931 | 43.414 ± 22.116 | 11.981 ± 3.408 |
All values are means ± SDs, and the number of samples was 8 unless otherwise indicated. Tmax, time until the maximum concentration was achieved; AUMCLAST, area under the first moment of the concentration-time curve determined to the last measured data point; MRTLAST, mean residence time using data to the last measured concentration.