TABLE 3.
Changes of ALT/AST/TBil after PPC injection.
| Categories | Multicenters | |||||
|---|---|---|---|---|---|---|
| PPC (N = 1,595) | PPC1 (N = 778) | PPC2 (N= 817) | PPC3 (N = 435) | PPC4 (N = 323) | PPC5 (N = 478) | |
| ALT recovery, n (%) | 277 (35.79) | 40 (18.69) | 237 (42.32) | 27 (20.77) | 16 (20.78) | 175 (39.24) |
| ALT change | ||||||
| Median (IQR) | −1 (−22–21) | 8 (−3–38) | −12 (−40–3) | 7 (−5–45) | 2 (−5–29) | −26 (−56–1) |
| Wilcoxon signed rank test, p value | −4.6 (0.000) | −11.4 (0.000) | −16.5 (0.000) | −7.6 (0.000) | −5.5 (0.000) | −14.7 (0.000) |
| AST recovery, n (%) | 302 (42.30) | 51 (17.59) | 251 (59.20) | 40 (22.47) | 24 (20.69) | 186 (58.68) |
| AST change | ||||||
| Median (IQR) | 0 (−17–26) | 10 (−3–51) | −8 (−48–6) | 9 (−4–64) | 4 (−5–42) | −23 (−95–4) |
| Wilcoxon signed rank test, p value | −8.8 (0.000) | −14.4 (0.000) | −18.6 (0.000) | −8.9 (0.000) | −7.3 (0.000) | −16.6 (0.000) |
| TBil recovery, n (%) | 184 (30.62) | 53 (17.04) | 131 (45.17) | 39 (21.91) | 28 (16.97) | 81 (47.37) |
| TBil change | ||||||
| Median (IQR) | 0 (−4–7) | 4 (0–12) | −2 (−8–2) | 4 (−1–12) | 3 (−2–11) | −2 (−10–1) |
| Wilcoxon signed rank test, p value | −8.3 (0.000) | −13.5 (0.000) | −9.6 (0.000) | −9.8 (0.000) | −7.4 (0.000) | −11.1 (0.000) |
Notes: PPC1 indicates using PPC injection alone and liver disease spectrum is “postoperation of tumor/liver transplantation”; PPC2 indicates using PPC injection alone, and liver disease spectrum is “postoperation of nontumor/liver transplantation”; PPC3 indicates using PPC injection alone, and liver disease spectrum is “viral hepatitis”; PPC4 indicates using PPC injection alone, and liver disease spectrum is “liver cirrhosis”; PPC5 indicates using PPC injection alone, and liver disease spectrum is “abnormal liver function”. ALT change indicates ALT level relative to baseline after treatment; ALT recovery indicates cases with abnormal ALT that changes to normal range (≤40 U/L) after treatment; AST change indicates AST level relative to baseline after treatment; AST recovery indicates cases with abnormal AST that changes to normal range (≤40 U/L) after treatment; TBil change indicates TBil level relative to baseline after treatment; TBil recovery indicates cases with abnormal TBil that changes to normal range (≤17.1 μmol/L) after treatment.
Abbreviations: IQR, interquartile range; PPC, polyene phosphatidyl choline; ALT, alanine transaminase; AST, aspartate aminotransferase; TBil, total bilirubin.