TABLE 1.

Potential drug intervention targets.

Intervention	Subjects	Location	Changes in metabolism	Potential mechanism	References
PMI 5011	C56BL/6J mice	Skeletal muscle cell	BW, HOME-IR, TG↓	Akt, PI3K↑	Yu et al. (2018)
S597	Ldlr−/− mice	Ly6Clo monocytes	OGTT, TG↓	IRS, PI3K, Akt↑	Kanter et al. (2018)
Vaspin	SD rats	Liver, skeletal muscle, adipose tissue	BW, Glu↓	p-IRS-1/IRS-1, p-IRS-2/IRS-2↓, p-Akt/Akt, Glut-4↑	Liu et al. (2018)
Melatonin	Wistar rats	Hepatic, skeletal muscle	WB, HDL↓	Akt, RISK↑, MAPK↓	Nduhirabandi et al. (2011)
WS-PE	C57BL/6J mice	Adipose tissues, skeletal muscles, cardiac muscle cells	WB, Glu, TC, TG, FFA, LDL↓	Akt, Glut-4, GSK↑	Lv et al. (2020)
Jujube fruits mixed	C57BL/6J mice	Liver	WB, Glu, TG, TC, VLDL↓	IRS-1, p-Akt/Akt↑	Jeong and Kim (2019)

↑ means that the inspection index or molecular level is higher than before the intervention; ↓ means that the inspection index or molecular level is lower than before the intervention.