TABLE 4.

Top 10 gut metabolism pathways affected by harmful bacteria subsequent addition of beneficial bacteria, and change in diet, and effect of oxidative stress on the gut and brain.

S. No.	Pathways affected by addition of beneficial bacteria to “purely” autistic gut	Pathways affected by change in diet	Pathways affected in the gut	Pathways affected in the brain
1	Purine catabolism	Purine catabolism	Purine catabolism	ROS detoxification
2	Nucleotide interconversion	Glycolysis/gluconeogenesis	Citric acid cycle	Oxidative phosphorylation
3	Glycolysis/gluconeogenesis	Fructose and mannose metabolism	Alanine and aspartate metabolism	Pyruvate metabolism
4	Citric acid cycle	Citric acid cycle	Purine synthesis	Glutamate metabolism
5	Valine, leucine, and isoleucine metabolism	Pyruvate metabolism	Vitamin B6 metabolism	NAD metabolism
6	Propanoate metabolism	Nucleotide interconversion	NAD metabolism	Citric acid cycle
7	Pyruvate metabolism	NAD metabolism	Pyrimidine catabolism	Urea cycle/amino group metabolism
8	Vitamin B6 metabolism	Purine synthesis	Glycolysis/gluconeogenesis	Alanine and aspartate metabolism
9	NAD metabolism	Vitamin B6 metabolism	Arginine and proline metabolism	Valine, leucine, and isoleucine metabolism
10	Purine synthesis	Pyrimidine catabolism	Nucleotide interconversion	Folate metabolism