TABLE 2.
The GO enrichment analysis of DEGs results between HSPB8 high expression group and low expression group. The pathways with p.adjust< 0.05 and qvalue< 0.05 are considered to be significantly enriched, showing the Top20 enrichment items of each category.
| Ontology | ID | Description | adj.P | q |
|---|---|---|---|---|
| BP | GO:0030198 | extracellular matrix organization | 6.58E-23 | 5.24E-23 |
| BP | GO:0043062 | extracellular structure organization | 6.58E-23 | 5.24E-23 |
| BP | GO:0010810 | regulation of cell-substrate adhesion | 1.51E-11 | 1.20E-11 |
| BP | GO:0031589 | cell-substrate adhesion | 2.59E-11 | 2.06E-11 |
| BP | GO:0010811 | positive regulation of cell-substrate adhesion | 6.47E-11 | 5.15E-11 |
| BP | GO:0050900 | leukocyte migration | 2.42E-10 | 1.92E-10 |
| BP | GO:0030199 | collagen fibril organization | 2.11E-09 | 1.68E-09 |
| BP | GO:0006959 | humoral immune response | 5.39E-08 | 4.29E-08 |
| BP | GO:0002685 | regulation of leukocyte migration | 7.17E-08 | 5.71E-08 |
| BP | GO:0006956 | complement activation | 2.02E-06 | 1.61E-06 |
| BP | GO:0003012 | muscle system process | 2.12E-06 | 1.69E-06 |
| BP | GO:0001503 | ossification | 2.12E-06 | 1.69E-06 |
| BP | GO:0045785 | positive regulation of cell adhesion | 2.59E-06 | 2.06E-06 |
| BP | GO:0006936 | muscle contraction | 3.98E-06 | 3.17E-06 |
| BP | GO:0061448 | connective tissue development | 4.15E-06 | 3.31E-06 |
| BP | GO:0051216 | cartilage development | 4.15E-06 | 3.31E-06 |
| BP | GO:0001101 | response to acid chemical | 4.15E-06 | 3.31E-06 |
| BP | GO:0060326 | cell chemotaxis | 6.16E-06 | 4.91E-06 |
| BP | GO:0006958 | complement activation, classical pathway | 6.16E-06 | 4.91E-06 |
| BP | GO:0002687 | positive regulation of leukocyte migration | 1.51E-05 | 1.20E-05 |
| CC | GO:0062023 | collagen-containing extracellular matrix | 4.75E-45 | 3.83E-45 |
| CC | GO:0043292 | contractile fiber | 1.05E-11 | 8.48E-12 |
| CC | GO:0030016 | Myofibril | 1.16E-10 | 9.35E-11 |
| CC | GO:0030017 | Sarcomere | 4.96E-10 | 4.00E-10 |
| CC | GO:0005788 | endoplasmic reticulum lumen | 7.19E-10 | 5.79E-10 |
| CC | GO:0005581 | collagen trimer | 1.35E-09 | 1.09E-09 |
| CC | GO:0031674 | I band | 5.74E-09 | 4.63E-09 |
| CC | GO:0030018 | Z disc | 1.01E-08 | 8.14E-09 |
| CC | GO:0072562 | blood microparticle | 5.36E-08 | 4.32E-08 |
| CC | GO:0005604 | basement membrane | 2.98E-07 | 2.40E-07 |
| CC | GO:0034774 | secretory granule lumen | 1.81E-06 | 1.46E-06 |
| CC | GO:0060205 | cytoplasmic vesicle lumen | 2.09E-06 | 1.68E-06 |
| CC | GO:0031983 | vesicle lumen | 2.17E-06 | 1.75E-06 |
| CC | GO:0031093 | platelet alpha granule lumen | 2.61E-05 | 2.11E-05 |
| CC | GO:0005796 | Golgi lumen | 2.85E-05 | 2.30E-05 |
| CC | GO:0005583 | fibrillar collagen trimer | 3.07E-05 | 2.47E-05 |
| CC | GO:0098643 | banded collagen fibril | 3.07E-05 | 2.47E-05 |
| CC | GO:0098644 | complex of collagen trimers | 3.07E-05 | 2.47E-05 |
| CC | GO:0031091 | platelet alpha granule | 4.79E-05 | 3.86E-05 |
| CC | GO:0032432 | actin filament bundle | 5.29E-05 | 4.26E-05 |
| MF | GO:0005201 | extracellular matrix structural constituent | 3.31E-29 | 2.82E-29 |
| MF | GO:0019838 | growth factor binding | 6.23E-10 | 5.32E-10 |
| MF | GO:0005539 | glycosaminoglycan binding | 7.45E-09 | 6.36E-09 |
| MF | GO:0008201 | heparin binding | 1.86E-08 | 1.58E-08 |
| MF | GO:0030020 | extracellular matrix structural constituent conferring tensile strength | 8.94E-08 | 7.62E-08 |
| MF | GO:1901681 | sulfur compound binding | 1.30E-07 | 1.10E-07 |
| MF | GO:0005178 | integrin binding | 3.55E-07 | 3.03E-07 |
| MF | GO:0061134 | Peptidase regulator activity | 5.31E-06 | 4.53E-06 |
| MF | GO:0019955 | cytokine binding | 8.02E-06 | 6.84E-06 |
| MF | GO:0005518 | collagen binding | 1.09E-05 | 9.30E-06 |
| MF | GO:0030021 | extracellular matrix structural constituent conferring compression resistance | 1.41E-05 | 1.20E-05 |
| MF | GO:0050840 | extracellular matrix binding | 1.72E-05 | 1.46E-05 |
| MF | GO:0050839 | cell adhesion molecule binding | 2.60E-05 | 2.22E-05 |
| MF | GO:0043394 | proteoglycan binding | 3.28E-05 | 2.79E-05 |
| MF | GO:0001968 | fibronectin binding | 4.88E-05 | 4.17E-05 |
| MF | GO:0048407 | platelet-derived growth factor binding | 6.68E-05 | 5.70E-05 |
| MF | GO:0003823 | antigen binding | 7.62E-05 | 6.50E-05 |
| MF | GO:0008307 | structural constituent of muscle | 0.000181 | 0.000155 |
| MF | GO:0004857 | enzyme inhibitor activity | 0.000268 | 0.000228 |
| MF | GO:0030414 | Peptidase inhibitor activity | 0.000299 | 0.000255 |