Table 2.

Key characteristics and outcomes of COVID-19–positive ACS registry studies

Study	Duration	Design	Size	Inclusion Criteria	Comparator Group	Treatment Delays	Diabetes Mellitus	OHCA	Cardiogenic Shock	In-Hospital Mortality	Other Key Findings
International COVID-ACS Registry Kite et al,23 2021	March 2020 – July 2020	Prospective, multicenter, international	144 STEMI, 121 NSTE-ACS	Only if underwent invasive angiography	Pre-COVID-19 BCIS and MINAP databases	Yes	36%	STEMI: 9% NSTE-ACS: 1%	STEMI: 20% NSTE-ACS: 5%	STEMI:23% NSTE-ACS: 7%	•High comorbidity burden in both ACS subgroups •Prolonged length of hospital stay in COVID-19–positive patients
NACMI Registry Garcia et al,28 2021	January 2020 – December 2020	Prospective, multicenter, United States & Canada	230 STEMI	Invasive angiography and medically managed patients	Historical propensity-matched cohort from Midwest STEMI Consortium	Yes	46%	11%	18%	33%	•COVID-19–positive patients more likely to be of minority ethnic origin •Lower rate of angiography in COVID-19–positive patients
Spanish Infarct Code Registry Rodriguez-Leor et al,30 2021	March 2020 – April 2020	Retrospective, multicenter, Spain	91 STEMI	Invasive angiography and medically managed patients	Contemporary COVID-19–negative controls	No	23%	8%	10%	23%	•COVID-19–positive patients more likely to undergo mechanical thrombectomy and receive GPIIb/IIIa inhibitors •COVID-19–positive patients had higher rates of in-hospital stent thrombosis
MINAP registry Rashid et al,29 2021	March 2020 – May 2020	Retrospective, multicenter, England	153 STEMI, 311 NSTE-ACS	Angiography and medically managed patients	Contemporary COVID-19 negative controls	Yes	38%	Combined STEMI/NSTE-ACS: 4%	Combined STEMI/NSTE-ACS: 10%	Combined STEMI/NSTE-ACS: 24%	•High comorbidity burden in both ACS subgroups •COVID-19–positive patients more likely to be of minority ethnic origin •Lower rate of angiography in COVID-19–positive patients

Abbreviations: ACS, acute coronary syndrome; BCIS, British Cardiovascular Intervention Society; MINAP, Myocardial Ischaemia National Audit Project; NACMI, North American COVID-19 Myocardial Infarction; NSTE-ACS, non–ST-elevation acute coronary syndrome; OHCA, out-of-hospital cardiac arrest; STEMI, ST-elevation myocardial infarction.