TABLE 2.

Antibacterial activities of LJC 11,036 against clinical isolates of gram-negative bacteria

Organism (no. of strains)	Drug	MICa (μg/ml)
		Range	50%	90%
E. coli (53)	LJC 11,036	≤0.025–0.1	≤0.025	0.05
	Imipenem	0.1–0.78	0.2	0.78
	Faropenem	0.2–3.13	0.78	3.13
	Cefdinir	0.1–50	0.39	1.56
	Levofloxacin	≤0.025–50	0.05	25
H. influenzae (50)	LJC 11,036	≤0.006–3.13	0.05	0.39
	Imipenem	0.025–12.5	0.78	3.13
	Faropenem	0.05–12.5	0.39	3.13
	Cefdinir	0.05–3.13	0.39	1.56
	Levofloxacin	≤0.006–0.025	≤0.006	0.013
K. pneumoniae (53)	LJC 11,036	≤0.025–0.2	≤0.025	0.05
	Imipenem	0.1–1.56	0.2	0.39
	Faropenem	0.2–6.25	0.78	1.56
	Cefdinir	0.1–0.78	0.2	0.2
	Levofloxacin	≤0.025–0.78	0.1	0.2
M. catarrhalis (53)	LJC 11,036	≤0.006–0.2	0.025	0.05
	Imipenem	0.013–0.39	0.05	0.1
	Faropenem	≤0.006–0.78	0.2	0.78
	Cefdinir	0.013–12.5	0.1	0.78
	Levofloxacin	≤0.006–0.2	0.05	0.2
E. cloacae (53)	LJC 11,036	0.013–3.13	0.05	0.2
	Imipenem	0.1–1.56	0.2	0.78
	Faropenem	0.39–25	3.13	12.5
	Cefdinir	0.39–>100	>100	>100
	Levofloxacin	0.013–50	0.1	6.25
P. mirabilis (53)	LJC 11,036	0.2–0.78	0.39	0.39
	Imipenem	1.56–12.5	6.25	12.5
	Faropenem	3.13–12.5	6.25	12.5
	Cefdinir	0.1–12.5	0.2	0.2
	Levofloxacin	0.05–>12.5	0.1	0.39
S. marcescens (54)	LJC 11,036	0.05–100	0.39	25
	Imipenem	0.39–>100	1.56	12.5
	Faropenem	0.78–>100	25	>100
	Cefdinir	1.56–>100	100	>100
	Levofloxacin	0.1–>100	0.78	50
P. aeruginosa (53)	LJC 11,036	3.13–>100	6.25	100
	Imipenem	0.39–25	1.56	25
	Faropenem	100–>100	>100	>100
	Cefdinir	>100	>100	>100
	Levofloxacin	0.2–>100	1.56	12.5

^aAgar dilution method.