TABLE 4.

Antibacterial activities of LJC 11,036 against β-lactamase-producing strains

β-Lactamasea and organism	MICb (μg/ml)
	LJC 11,036	Imi-penem	Faro-penem	Cef-dinir	Levo-floxacin
PCase
Escherichia coli
TEM-1	≤0.025	0.20	0.78	0.20	0.39
TEM-2	≤0.025	0.39	0.78	0.39	0.39
OXA-1	≤0.025	0.20	0.78	0.20	0.39
OXA-2	0.05	0.20	0.78	0.78	0.39
PSE-1	≤0.025	0.20	0.39	0.20	0.39
PSE-3	≤0.025	0.39	0.78	0.20	0.39
SHV-1	≤0.025	0.39	0.78	0.39	0.39
Staphylococcus aureus
ML15009	≤0.025	≤0.025	0.05	0.05	0.20
ML15009/pI258	≤0.025	≤0.025	0.05	0.05	0.20
Klebsiella pneumoniae GN69	≤0.025	0.39	0.39	0.05	0.05
ESBL (Klebsiella pneu-moniae LJ11c)	0.05	0.10	3.13	>100	0.78
CEPase
Escherichia coli
GN5482	≤0.025	0.20	0.39	6.25	0.05
No. 1501	≤0.025	0.20	0.20	0.20	0.05
No. 96	≤0.025	0.20	0.39	6.25	0.05
Enterobacter cloacae
GN5797	0.05	0.39	1.56	100	0.10
GN7467	0.10	0.39	1.56	50	0.05
GN7471	≤0.025	0.20	0.39	100	0.05
Citrobacter freundii
GN346	0.05	0.39	1.56	25	0.05
GN7391	0.10	0.78	6.25	>100	0.20
Serratia marcescens
GN10857	0.78	6.25	25	>100	0.20
L-65	0.10	0.78	1.56	1.56	≤0.025
L-82	0.05	0.20	3.13	>100	0.05
Providencia rettgeri
GN4430	0.10	0.39	0.78	≤0.025	0.20
GN4762	0.39	0.39	3.13	≤0.025	0.10
GN5284	0.10	0.78	0.39	≤0.025	0.20
Morganella morganii
GN5307	0.10	1.56	0.78	1.56	0.05
GN5375	0.39	1.56	0.78	1.56	≤0.025
GN5407	0.20	6.25	0.78	6.25	0.10
Proteus vulgaris
GN76	0.39	6.25	6.25	0.10	0.05
GN4413	0.39	6.25	6.25	50	0.05
GN7919	0.39	0.39	0.78	3.13	0.05
Pseudomonas aeru-ginosa
GN918	6.25	1.56	>100	>100	1.56
GN10362	1.56	1.56	>100	>100	0.39
GN10367	3.13	1.56	>100	>100	0.39
CBPase
Stenotrophomonas mal-tophilia GN12873	>100	>100	>100	>100	0.39
Pseudomonas aeru-ginosa
LJ21d	>100	50	>100	>100	50
LJ23d	>100	50	>100	>100	>100

^aPCase, penicillinase; CEPase, cephalosporinase; CBPase, carbapenemase. 

^bAgar dilution method. 

^cTOHO-1 type. 

^dIMP-1 type.