Table 3.

Multivariate linear mixed effects model of post-transfusion HbA decline

	Univariate General Linear Model		Multivariate Mixed Effects Model
	Parameter estimate (g/dL/week)	p-value	Parameter estimate (g/dL/week)	p-value
No splenectomy	0.107	<0.0001	0.096	0.0022
Extended RBC antigen matching	0.066	0.0045	0.050	0.380
Transfusion characteristics (fraction of units/transfusion)
Severe G6PD deficiency	0.267	0.0013	0.162	0.0238
Moderate or severe G6PD deficiency	0.102	0.034
Fy-null	0.066	0.038	0.055	0.139
S-negative	0.061	0.054
U-negative	−0.24	0.28

The decline in HbA (ΔHbA) was represented as the change in HbA (g/dL) from immediate post transfusion to the next scheduled transfusion time point, divided by the number of days between the 2 post-transfusion time points. ΔHbA units were then converted to g/dL/week for this analysis. For the multivariate model, only severe G6PD deficiency (not moderate G6PD deficiency) of donor units was introduced to the model.