Table 2.
Knee Replacement Surgery over Five Years Among Participants Initiating PPI (Omeprazole, Pantoprazole, Lansoprazole, Rabeprazole, or Esomeprazole) Compared with Initiation of H2RA
| Omeprazole vs. H2RA | Pantoprazole vs. H2RA | Lansoprazole vs. H2RA | Rabeprazole vs. H2RA | Esomeprazole vs. H2RA | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Participant (n) | 2,672 | 2,672 | 664 | 664 | 3,747 | 3,747 | 751 | 751 | 827 | 827 |
| KR case (n) | 274 | 230 | 90 | 65 | 372 | 357 | 91 | 92 | 68 | 81 |
| Mean follow-up (year) | 3.33 | 3.39 | 3.40 | 3.42 | 3.14 | 3.26 | 3.80 | 3.80 | 3.31 | 3.28 |
| Rate (/1000 person-years) | 30.8 | 25.4 | 39.8 | 28.6 | 31.6 | 29.2 | 31.9 | 32.3 | 24.8 | 29.9 |
| 1.21 | 1.00 | 1.38 | 1.00 | 1.06 | 1.00 | 0.97 | 1.00 | 0.83 | 1.00 | |
| HR, (95% CI) # * | (1.01, 1.44) | (reference) | (1.00, 1.90) | (reference) | (0.92, 1.23) | (reference) | (0.73, 1.30) | (reference) | (0.60, 1.15) | (reference) |
| PS trimming, | 1.23 | 1.00 | 1.43 | 1.00 | 1.06 | 1.00 | 0.97 | 1.00 | 0.79 | 1.00 |
| HR, (95% CI) # * | (1.03, 1.48) | (reference) | (1.03, 1.98) | (reference) | (0.91, 1.23) | (reference) | (0.72, 1.30) | (reference) | (0.57, 1.11) | (reference) |
| Missing data imputation, | 1.18 | 1.00 | 1.38 | 1.00 | 1.15 | 1.00 | 1.09 | 1.00 | 0.87 | 1.00 |
| HR, (95% CI) # * | (1.01, 1.39) | (reference) | (1.03, 1.85) | (reference) | (0.98, 1.34) | (reference) | (0.77, 1.55) | (reference) | (0.63, 1.21) | (reference) |
n, number; KR, knee replacement; HR, Hazard Ratio; CI, confidence interval; PS, propensity score; PPI, proton pump inhibitor; H2RA, Histamine-2 receptor antagonist.
#
Results from propensity score matched cohort study (i.e., intent-to-treat approach).
*
Adjusting for competing risk of death.