Table 3.

Knee Replacement Surgery over Five Years Among Participants Initiating Omeprazole, Pantoprazole, Lansoprazole, or Rabeprazole Compared with Initiation of Esomeprazole

	Omeprazole vs. Esomeprazole		Pantoprazole vs. Esomeprazole		Lansoprazole vs. Esomeprazole		Rabeprazole vs. Esomeprazole
Participant (n)	699	699	1,006	1,006	862	862	657	657
KR case (n)	90	60	114	85	84	71	72	58
Mean follow-up (year)	3.58	3.39	3.45	3.49	3.44	3.55	3.98	3.98
Rate (/1000 person-years)	37.1	23.7	32.8	24.2	28.3	23.2	27.6	22.2
HR, (95% CI) # *	1.57	1.00	1.37	1.00	1.20	1.00	1.24	1.00
	(1.13, 2.17)	(reference)	(1.03, 1.81)	(reference)	(0.88, 1.65)	(reference)	(0.88, 1.75)	(reference)

n, number; KR, knee replacement; HR, Hazard Ratio; CI, confidence interval; PS, propensity score; PPI, proton pump inhibitor; H2RA, Histamine-2 receptor antagonist.

^#Results from propensity score matched cohort study (i.e., intent-to-treat approach).

^*Adjusting for competing risk of death.