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. 2021 Sep 23;163(6):e759–e773. doi: 10.1097/j.pain.0000000000002480

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Copyright © 2021 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the International Association for the Study of Pain.

This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Case–control differences in global morphometric similarity. In the upper panel, we present case and control distributions of the residual regional morphometric similarity (MS) strength (ie, the average similarity of each region to all other regions) after regressing out the effects of age, gender, and intracranial volume, for each data set separately. In the lower panel, we present case–control comparisons of the global MS. To calculate global MS, we averaged the residual regional MS strength across all regions for each subject. In all 3 data sets, there were no differences between groups in global MS. A, osteoarthritis dataset; B, chronic low back pain dataset; C, fibromyalgia dataset. CLBP, chronic low back pain; HC, healthy controls; OA, osteoarthritis.