Table 1.

List of Uncovered Compounds with Potential Anti-Covid-19 Activities Following COMPARE Analysis.

Seeded Drug	Correlated Drug “Preys”	Pearson Correlation	Reported Pharmacological Effects
	Lucanthonea	0.55	Antineoplastic, anti-infective, antiparasitic, autophagy inhibitor
	Amiodaronea	0.59	Antiarrhythmic and vasodilatory
	Oxycanthineb	0.56	An alkaloid from fruits (Berberis) with antimicrobial, hepatoprotective, and immunomodulatory activities25
	Pheanthineb	0.60	An alkaloid from traditional Peruvian medicine with antineoplastic and antiparasitic activities
	Thiothixenea	0.56	Antipsychotic
	Lapacholb	0.60	Natural naphthoquinone with antimalaria and antiviral activities14
	Ethacizinea	0.56	A phenothiazine with antiarrhythmic activities
	Methotrexatea	0.67	Antineoplastic and immunosuppressant activities
	Azaribinea	0.61	Antineoplastic and antipsoriatic activities
	Brequinara	0.61	Antineoplastic
	Retinola	0.80	Vitamin A
	Flucloxacillina	0.79	A penicillin antibiotic
	Didanosinea	0.78	A reverse transcriptase inhibitor used to treat HIV
	Uridinea	0.72	A natural nucleoside used as a supplement
	1-adamantyl 2-methyl-2-propanesulfinate	0.77	Adamantine derivative (experimental drug)
	Brucineb	0.67	An alkaloid found in Strychnos nux-vomica tree with antineoplastic, antiviral, and anti-inflammatory activities26
	Coumestrolb	0.65	A coumestan derivative with estrogen-like activities (phytoestrogens) made by some plants; coumestans may have anticancer effects
	Hydrocortisonea	0.97	Corticosteroids
	Fluocinolone acetonidea	0.81
	Betamethasonea	0.80
	Methylprednisolonea	0.73
	Flumethasonea	0.69
	Triamcinolonea	0.66
	Cortivazola	0.63
	Scopolamine N-oxidea hydrobromidea	0.66	Anti-Parkinson and antimuscarinic agent
	Nicotinamidea	0.66	Vitamine B3
	Succimera	0.64	An orally active, heavy metal chelating agent
	2′-Deoxyuridinea	0.64	Antimetabolite
	Valproic acida	0.52	Antiepileptic and potential antineoplastic and antiangiogenic

^aIndicates existing clinically approved drugs.

^bIndicates active principles in medicinal plants.