Table 2.

Association of the schizophrenia and major depression polygenic risk scores with childhood adversities in the Generation R Study (N = 1901)

	Childhood adversities
	OR (95% CI)	P	PFDR
Generation R study (N = 1901)
Total adversities	1.08 (1.02–1.15)	0.01	–
Person-related adversities	1.06 (0.97–1.16)	0.18	0.24
Environment-related adversities	1.01 (0.90–1.14)	0.87	0.87
Adversities before age 5 years	1.20 (1.05–1.36)	0.01	0.04
Adversities after age 5 years	1.05 (0.98–1.13)	0.13	0.24
Major depression risk score
Total adversities	1.03 (0.97–1.10)	0.33	–
ALSPAC study (N = 3641)
Total adversities	1.02 (1.01;1.03)	< 0.01	–

Note. Analyses are adjusted for age, child sex, and four principal components of genetic ancestry. Results are shown for the P_t < 0.5 inclusion threshold. Results for the other P-value thresholds are shown Supplementary Material