Table 3.

The mediating effect of childhood adversity in the association between the schizophrenia polygenic risk score and childhood problem behaviour

Outcome	Total effect			Direct effect		Mediated effect		Proportion mediated
	β (95% CI)	P	PFDR	β (95% CI)	P	β (95% CI)	P	Estimate (95% CI)	P
Generation R Study (N = 1901)
Internalizing problems	0.06 (0.02;0.11)	0.01	–	0.05 (0.01;0.09)	0.02	0.01 (0.00;0.03)	0.05	0.22 (-0.01;0.65)	0.06
Anxious/depressed	0.06 (0.02;0.10)	0.01	0.02	0.05 (0.00;0.09)	0.03	0.01 (0.00;0.03)	0.05	0.23 (0.00;0.77)	0.05
Withdrawn/depressed	0.00 (− 0.04;0.04)	0.97	0.97	NA	NA	NA
Somatic complaints	0.05 (0.01;0.10)	0.02	0.03	0.04 (0.00;0.09)	0.06	0.01 (0.00;0.02)	0.04	0.19 (− 0.02;0.83)	0.06
Externalizing problems	0.04 (0.00;0.09)	0.06	–	NA	NA	NA
Other problems scales
Social problem	0.04 (− 0.01;0.08)	0.11	0.13	NA	NA	NA
Thought problems	0.08 (0.04;0.12)	< 0.01	< 0.01	0.07 (0.03;0.11)	< 0.01	0.01 (0.00;0.02)	0.05	0.14 (0.00;0.34)	0.05
Attention problems	0.07 (0.02;0.11)	< 0.01	< 0.01	0.05 (0.01;0.10)	0.01	0.01 (0.00;0.02)	0.04	0.19 (0.01;0.54)	0.04
ALSPAC cohort (N = 3447)
SDQ Prosocial behaviour	− 0.05 (− 0.09;− 0.02)	< 0.01	–	− 0.05 (− 0.08;− 0.02)	< 0.01	− 0.003 (− 0.01;0.00)	0.01	0.05 (0.01;0.16)	0.01

Note. Analyses are adjusted for age, child sex, and four principal components of genetic ancestry. Results are shown for the P_t < 0.5 inclusion threshold

NA  not applicable (due to the fact that the result was not significant in the total effect analyses)