Table 4.

The mediating effect of childhood adversity before age 5 years in the association between the schizophrenia polygenic risk score and childhood problem behaviour

Outcome	Total effect			Direct effect		Mediated effect		Proportion mediated
	β (95% CI)	P	PFDR	β (95% CI)	P	β (95% CI)	P	Estimate (95% CI)	P
Internalizing problems	0.05 (0.01;0.10)	0.03	–	0.04 (0.00;0.08)	0.05	0.01 (0.00;0.02)	0.02	0.22 (0.04;0.87)	0.03
Anxious/depressed	0.06 (0.01;0.10)	0.01	0.02	0.05 (0.00;0.09)	0.04	0.01 (0.00;0.02)	0.01	0.19 (0.04;0.73)	0.02
Withdrawn/depressed	0.00 (− 0.04;0.05)	0.95	0.95	NA	NA	NA
Somatic complaints	0.05 (0.01;0.10)	0.02	0.03	0.04 (0.00;0.09)	0.05	0.01 (0.00;0.02)	0.01	0.15 (0.02;0.70)	0.03
Externalizing problems	0.03 (− 0.01;0.07)	0.17	–	NA	NA	NA
Other problems
Social problems	0.04 (-0.01;0.08)	0.10	0.12	NA	NA	NA
Thought problems	0.07 (0.03;0.12)	< 0.01	< 0.01	0.06 (0.02;0.11)	0.01	0.01 (0.00;0.02)	0.01	0.14 (0.03;0.40)	0.01
Attention problems	0.07 (0.02;0.11)	< 0.01	< 0.01	0.06 (0.01;0.10)	0.01	0.01 (0.00;0.02)	0.02	0.14 (0.03;0.43)	0.02

Note. Analyses are adjusted for age, child sex, and four principal components of genetic ancestry. Results are shown for the P_t < 0.5 inclusion threshold

NA  not applicable (due to the fact that the result was not significant in the total effect analyses)