Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Mar 22;12:4890. doi: 10.1038/s41598-022-09028-9

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Conceptual model and geometry. (a) The local fluid exchange between the interstitium and the capillaries and initial lymphatic vessels is represented as a distributed source/sink without explicitly representing individual blood or lymph vessels. (b) Simplified, axisymmetric geometries of the lower leg used in the model. The bone is assumed to provide a rigid, impermeable surface at the inner boundary of the soft tissues. The soft tissue may move radially and vertically at the upper and outermost boundaries, but can move only radially at the lower boundary. Fluid can enter or leave the system locally via the blood and lymph vessels or through the interstitium at the upper boundary. All other boundaries are impermeable.