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. 2022 Mar 22;12:4890. doi: 10.1038/s41598-022-09028-9

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© The Author(s) 2022

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Map based on Eq. (14) showing how vascular absorption dominates at the baseline conditions of high tissue stiffness K and low tissue permeability $κ$ , while gravity-driven pooling in the interstitium dominates for low tissue stiffness and high tissue permeability that can arise from dilation of the interstitial pore space. The lines of constant $β = β_{c} + β_{L}$ determine when transition from vascular absorption dominance to gravity dominance occurs with the baseline conditions indicated by $1 β$ .