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. 2022 Mar 22;8:36. doi: 10.1038/s41523-022-00391-4

Table 1.

Actual incidence rates and estimated rate differences for individuals without a family history between NHB and NHW women by age and breast cancer molecular subtype.

NHB Incidence/100,000 NHW Incidence/100,000 Estimated incidence in NHB without family history (Per 100,000) Estimated incidence in NHW without family history (Per 100,000) Estimated Rate difference
Overall
 TNBC 38 19 31.2 12.5 18.7
 Luminal A (HR+, HER2−) 112 138 94.1–96.9 107.1 −13 to −10.2
 Luminal B (HR+, HER2+) 21 20 17.6–18.2 15.5 2.1–2.7
 HER2+/enriched (HR−, HER2+) 10 8 8.4–8.7 6.2 2.2–2.5
<40 years
 TNBC 9.7 5.7 8 3.8 4.2
 Luminal A 17.8 17.9 15–15.4 13.9 1.1–1.5
 Luminal B 6.7 6.6 5.6–5.8 5.1 0.5–0.7
 HER2+/enriched 2.6 2.4 2.2 1.9 0.3
40–54 years
 TNBC 34.6 17.5 28.4 11.6 16.8
 Luminal A 84.4 113.3 70.9–73 87.9 −17 to −14.9
 Luminal B 19.9 20.4 16.7–17.2 15.8 0.9-1.4
 HER2+/enriched 10.4 7.6 8.7–9 5.9 2.8–3.1
55–69 years
 TNBC 52.6 25.1 43.1 16.6 26.5
 Luminal A 164.3 207.9 138-142.1 161.3 −23.3 to −19.2
 Luminal B 30.3 27.1 25.5-26.2 21 4.5-5.2
 HER2+/enriched 14.9 11.3 12.5-12.9 8.8 3.7-4.1
70–84 years
 TNBC 49.6 27.8 43.1 16.6 22.4
 Luminal A 214.1 268 138–142.1 161.3 −28.2 to −22.8
 Luminal B 25.4 25.3 25.5–26.2 21 1.7–2.4
 HER2+/enriched 14.7 9.9 12.5–12.9 8.8 4.6-5

FH% is 18%40, 13.5–16%27,40, 22.4%27, and 34%41 for NHB TNBC all ages, NHB FH for other BC subtypes all ages, NHW other subtypes all ages, and NHW TNBC all ages, respectively; Incidence data sources3,39.