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. 2022 Mar 22;12:4853. doi: 10.1038/s41598-022-08949-9

Figure 2.

Figure 2

Anti-CD80/86 antibodies reduce pro-inflammatory cytokine production in mixed lymphocyte reaction. (a) IFN-γ production reduced by anti-CD80/86 antibodies compared with that without anti-CD80/86 antibodies (n = 3, **P = 0.005, N.S, P > 0.999, respectively). (b) IL-1β production reduced by anti-CD80/86 antibodies compared to that without anti-CD80/86 antibodies (n = 3, **P = 0.003, *P = 0.021, respectively). (c) IL-2 production reduced by anti-CD80/86 antibodies compared to that without anti-CD80/86 antibodies (n = 3, *P = 0.012, ***P < 0.001, respectively). (d) IL-10 production reduced by anti-CD80/86 antibodies compared with that without anti-CD80/86 antibodies (n = 3, **P = 0.004, ***P < 0.001, respectively). (e) TNF-α production reduced by anti-CD80/86 antibodies compared with that without anti-CD80/86 antibodies (n = 3, **P = 0.010, ***P < 0.001, respectively). (f) IL-12 production did not change between the groups (n = 3, P = 0.530).