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. 2022 Mar 22;12:4840. doi: 10.1038/s41598-022-08948-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Trap staining of skull slices after treatment with TXA at different concentrations 24 h after 3 injections. Scale bar: 50 μm (above) and 20 μm (below). (B) Quantification of osteoclast activation in skull slices. The results were quantified as the mean of three independent experiments and analysed by one-way ANOVA (*p < 0.05 indicates statistical significance).