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. 2022 Mar 22;12:4922. doi: 10.1038/s41598-022-08806-9

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Blood flow changes in Gabrb3^ECKO mice. (a) Schematic of blood flow velocity acquisition by MPLSM. Using TAMRA–dextran contrast enhanced angiography; region of interest is first identified. Then, line scan images along the central axis of individual blood vessels (x-t) are acquired. Dark streaks (negative contrast) correspond to RBCs moving along the central axis of the blood vessel. The slopes of these streaks correspond to the RBC velocities. Data are presented in violin plots (*P < 0.05, Student's t-test). (b) Violin plot showing distribution of RBC velocities in capillaries (n = 22, n = 13 vessels, respectively). (c) Violin plot showing distribution of blood flow in capillaries of Gabrb3^fl/fl and Gabrb3^ECKO mice (n = 22, n = 12 vessels, respectively). (e–g) Histograms of RBC velocity and blood flow in the capillaries in the Gabrb3^fl/fl versus Gabrb3^ECKO mice.