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. 2022 Mar 22;12:4344. doi: 10.1038/s41598-022-08583-5

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Intracellular observation of MITO-Porter (RES). (A) Cellular uptake of RP/S2-MITO-Porter (RES), S2-MITO-Porter (RES) and DOPE/SM-LP (RES) labeled with NBD-lipids were evaluated by flow cytometry, using CPCs. The quantitative analysis of cellular uptake using the mean fluorescence intensity (MFI) of the carriers. Data are represented as the mean with S.D. (n = 3). The significant differences were calculated using one-way ANOVA followed by SNK test (**p < 0.01). (B) Intracellular observation of DOPE/SM-LP (RES) (a–c), S2-MITO-Porter (RES) (d–f) and RP/S2-MITO-Porter (RES) (g–i) using CLSM. When green labeled carriers (green color) were co-localized with red stained mitochondria, yellow signals were observed in the merged image. Lines indicate the edges of the cells. Scale bars 20 μm.