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. 2022 Mar 22;12:4344. doi: 10.1038/s41598-022-08583-5

Figure 5.

Figure 5

Evaluation of therapeutic effect after cell transplantation. (A) Body weight of mice after ischemic perfusion. This figure shows the change in body weight at 30 days after transplantation of each group (PBS treated group (n = 7), CPC group (n = 6), MITO-cell group (n = 6)) in an ischemia–reperfusion mouse model. Data are represented as the mean with S.D. (n = 6–7). *Significant differences were calculated by one-way ANOVA, followed by SNK test (p < 0.05). (B) Evaluation of cardiac function of ischemic myocardium. (a) Echocardiographic image in 30 days after cell transplantation in ischemia reperfusion model mice. (i) Sham operation mice, (ii) PBS treated, (iii) CPC transplanted and (iv) MITO cell transplanted ischemic reperfusion model mice. Scale bars 2 mm. (b) Comparison of fraction shortening among these groups. Fraction shortening (%) was estimated by two-dimension (see “Methods” section for the detail). Sham; Sham operation mice (n = 11), PBS; PBS treated (n = 5), CPC CPC transplanted (n = 6) and MITO cell MITO cell transplanted (n = 6) ischemic reperfusion model mice group. Data are represented as the mean ± S.D. Significant differences (*p < 0.05, **p < 0.01) were calculated by one-way ANOVA, followed by SNK test.