Table 1.
Particle properties of the carriers encapsulating RES used in this study.
| Carrier type | Liposome composition (molar ratio) | Diameter (nm) | Polydispersity index | ζ-potential (mV) |
|---|---|---|---|---|
| RP/S2-MITO-Porter (RES) | DOPE:SM:STR-S2:Chol-RP:Resveratorl (9:2:1.1:0.1:2) | 126 ± 2 | 0.15 ± 0.05 | − 45 ± 2 |
| S2-MITO-Porter (RES) | DOPE:SM:STR-S2:Resveratorl (9:2:1.1:2) | 107 ± 11 | 0.26 ± 0.01 | + 34 ± 3 |
| DOPE/SM-LP (RES) | DOPE:SM (9:2) | 129 ± 4 | 0.13 ± 0.04 | − 16 ± 3 |
Size, PDI, and ζ potential of each particles were measured. DOPE 1,2-dioleoyl-sn-glycerol-3-phosphatidyl ethanolamine, Chol-RP cholesteryl RP aptamer, SM sphingomyelin, STR-S2 stearylated S2 Peptide. S2 peptide sequence: (Dimethyl-Tyr)-(D-Arg)-(Phe)-(Lys)-(Dimethyl-Tyr)-(D-Arg)-(Phe)-(Lys)-NH2. RP aptamer sequence: 5′-UCUCCCUGAGCUUCAGG-3′. Data are represented as mean with S.D. (n = 7).