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. 2022 Mar 22;8:125. doi: 10.1038/s41420-022-00933-6

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A A significantly enriched KEGG pathways and WIKI pathways target of MYH9 co-expression genes in RCC. B GSEA analysis showed impact of MYH9 on the AKT signaling pathway. C A Pearson test was used to analyze correlations between MYH9 and genes differentially expressed in RCC. D Western blotting analysis of the indicated proteins in 293-T cells transfected with LV-ctrl or LV-MYH9 (n = 3). E Luciferase activity assay of AKT luciferase reporter plasmids in 293-T cells transfected with LV-ctrl or LV-MYH9. F Western blotting analysis of the indicated proteins in 786-O xenografts transfected with LV-ctrl (C1-3) or LV-MYH9 (L1-3). G CCK8 assay of control and MYH9 knockdown ccRCC cells at indicated times along with vehicle or SC79 (5 μM) treatment. H Wound-healing assay of control and MYH9 knockdown ccRCC cells along with vehicle or SC79 (5 μM) photographed at 0, 24, and 48 h after scratching. Scale bar = 500 μm.