. 2022 Mar 22;12:4919. doi: 10.1038/s41598-022-09015-0

Table 4.

Mean relative abundance of the predicted functions of the bacterial communities grouped according to KEGG pathway categories among the three study groups.

Level 1	Level 2	Corrected P-value	Control	F0	F1
Cellular Processes	Cell Growth and Death	6.54E−07	1.21 ± 0.03^a	1.25 ± 0.02^a	0.51 ± 0.04^b
	Cell Motility	0.8015	0.85 ± 0.09	0.76 ± 0.05	0.79 ± 0.22
	Transport and Catabolism	3.43E−06	0.26 ± 0.00^b	0.26 ± 0.00^b	0.41 ± 0.01^a
Environmental Information Processing	Membrane Transport	0.0006	10.37 ± 0.30^b	10.08 ± 0.16^b	11.88 ± 0.24^a
	Signal Transduction	2.94E−07	1.08 ± 0.07^b	1.01 ± 0.03^b	1.64 ± 0.02^a
	Signaling Molecules and Interaction	3.92E−06	0.01 ± 0.00^b	0.01 ± 0.00^b	0.17 ± 0.00^a
Genetic Information Processing	Folding, Sorting and Degradation	1.65E−07	3.94 ± 0.06^a	3.98 ± 0.02^a	2.34 ± 0.08^b
	Replication and Repair	8.44E−06	11.52 ± 0.19^a	11.69 ± 0.09^a	6.97 ± 0.30^b
	Transcription	0.0097	1.96 ± 0.02	1.94 ± 0.01	2.04 ± 0.05
	Translation	1.97E−08	9.22 ± 0.19^a	9.39 ± 0.09^a	4.43 ± 0.22^b
Human Diseases	Cancers	1.02E−07	0.56 ± 0.02^a	0.58 ± 0.01^a	0.15 ± 0.02^b
	Cardiovascular Diseases	3.35E−06	0.08 ± 0.00^a	0.08 ± 0.00^a	0.01 ± 0.01^b
	Immune System Diseases	5.65E−07	0.01 ± 0.00^b	0.01 ± 0.00	0.06 ± 0.00^a
	Infectious Diseases	2.15E−09	0.55 ± 0.00^a	0.55 ± 0.00^a	0.36 ± 0.01^b
	Metabolic Diseases	1.00E−07	0.09 ± 0.00^b	0.09 ± 0.00^b	0.11 ± 0.11^a
	Neurodegenerative Diseases	0.0006	1.19 ± 0.04^a	1.22 ± 0.02^a	0.25 ± 0.03^b
Metabolism	Amino Acid Metabolism	5.69E−10	8.96 ± 0.04^b	9.00 ± 0.03^b	12.05 ± 0.06^a
	Biosynthesis of Other Secondary Metabolites	5.28E−07	0.48 ± 0.01^b	0.48 ± 0.00^b	0.85 ± 0.03^a
	Carbohydrate Metabolism	1.09E−07	7.73 ± 0.08^b	7.66 ± 0.04^b	10.53 ± 0.14^a
	Energy Metabolism	7.83E−08	7.74 ± 0.10^a	7.83 ± 0.05^a	5.33 ± 0.07^b
	Enzyme Families	0.0021	1.70 ± 0.01^b	1.69 ± 0.01^b	1.85 ± 0.05^a
	Glycan Biosynthesis and Metabolism	0.0097	1.28 ± 0.03^a	1.24 ± 0.02^a	1.17 ± 0.01^b
	Lipid Metabolism	1.00E−07	2.67 ± 0.01^b	2.68 ± 0.00^b	4.27 ± 0.09^a
	Metabolism of cofactors and vitamins	0.0359	4.65 ± 0.02^a	4.67 ± 0.01^a	4.46 ± 0.11^b
	Metabolism of other amino acids	6.75E−07	1.33 ± 0.01^b	1.33 ± 0.00^b	2.33 ± 0.07^a
	Metabolism of terpenoids and polyketides	5.54E−07	1.91 ± 0.02^b	1.94 ± 0.01^b	2.62 ± 0.05^a
	Nucleotide metabolism	1.04E−06	5.51 ± 0.09^a	5.59 ± 0.04^a	3.57 ± 0.13^b
	Xenobiotics biodegradation and metabolism	1.42E−06	1.49 ± 0.03^b	1.49 ± 0.01^b	5.49 ± 0.38^a
Organismal Systems	Circulatory system	1.75E−08	0.23 ± 0.01^a	0.24 ± 0.00^a	0.01 ± 0.00^b
	Digestive system	6.41E−08	0.00 ± 0.00^b	0.00 ± 0.00^b	0.03 ± 0.00^a
	Endocrine system	2.42E−07	0.11 ± 0.01^b	0.11 ± 0.00^b	0.56 ± 0.03^a
	Environmental adaptation	4.17E−09	0.25 ± 0.00^a	0.26 ± 0.00^a	0.09 ± 0.00^b
	Excretory system	2.65E−10	0.00 ± 0.00^b	0.00 ± 0.00^b	0.08 ± 0.00^a
	Immune system	1.65E−07	0.16 ± 0.00^a	0.17 ± 0.00^a	0.05 ± 0.00^b
	Nervous system	8.44E−06	0.08 ± 0.00^b	0.08 ± 0.00^b	0.13 ± 0.00^a
Unclassified	Cellular processes and signaling	0.0002	3.65 ± 0.05^a	3.50 ± 0.03^a	3.08 ± 0.07^b
	Genetic information processing	8.44E−06	2.28 ± 0.00	2.28 ± 0.00	2.01 ± 0.03
	Metabolism	3.92E−06	1.71 ± 0.03^b	1.69 ± 0.01^b	2.60 ± 0.09^a
	Poorly characterized	0.0359	0.00 ± 0.00^b	3.16 ± 0.04^b	4.78 ± 0.11^a

Different letters in the same row indicate statistical significance between taxonomic abundance of predicted functions based on STAMP analysis using ANOVA followed by Tukey–Kramer and Benjamini–Hochberg correction (P < 0.05).